Compatibility analysis for the 1535-1660 MHz band, part 1 Final report, Jan. - Sep. 1969

Electromagnetic compatibility and radio frequency interference of aircraft radio antenna

Combining pot, atom and step economy (PASE) in organic synthesis. Synthesis of tetrahydropyran-4-ones

The combination of pot, atom and step economy (PASE) in the synthesis of organic molecules of medium complexity can lead to a significant 'greening' of a synthetic route. This is demonstrated by the synthesis of highly substituted tetrahydropyran-4-ones and is quantified by a series of recognised metrics, which demonstrate the efficiency of combining PASE over conventional synthetic strategies

Optical and RF Metrology for 5G

Specification standards will soon be available for 5G mobile RF communications. What optical and electrical metrology is needed or available to support the development of the supporting optical communication systems? Device measurement, digital oscilloscope impairments and improving system resolution are discussed.Comment: 2017 IEEE Photonics Society Summer Topical Meeting Series (SUM

Assessing consistency of fish survey data : uncertainties in the estimation of mackerel icefish (Champsocephalus gunnari) abundance at South Georgia

Acknowledgments The authors wish to thank the crews, fishermen and scientists who conducted the various surveys from which data were obtained, and Mark Belchier and Simeon Hill for their contributions. This work was supported by the Government of South Georgia and South Sandwich Islands. Additional logistical support provided by The South Atlantic Environmental Research Institute with thanks to Paul Brickle. Thanks to Stephen Smith of Fisheries and Oceans Canada (DFO) for help in constructing bootstrap confidence limits. Paul Fernandes receives funding from the MASTS pooling initiative (The Marine Alliance for Science and Technology for Scotland), and their support is gratefully acknowledged. MASTS is funded by the Scottish Funding Council (grant reference HR09011) and contributing institutions. We also wish to thank two anonymous referees for their helpful suggestions on earlier versions of this manuscript.Peer reviewedPostprin

Eicosapentaenoic acid and oxypurinol in the treatment of muscle wasting in a mouse model of cancer cachexia

Cancer cachexia is a wasting condition, driven by systemic inflammation and oxidative stress. This study investigated eicosapentaenoic acid (EPA) in combination with oxypurinol as a treatment in a mouse model of cancer cachexia. Mice with cancer cachexia were randomized into 4 treatment groups (EPA (0.4 g/kg/day), oxypurinol (1 mmol/L ad-lib), combination, or control), and euthanized after 29 days. Analysis of oxidative damage to DNA, mRNA analysis of pro-oxidant, antioxidant and proteolytic pathway components, along with enzyme activity of pro- and antioxidants were completed on gastrocnemius muscle. The control group displayed earlier onset of tumor compared to EPA and oxypurinol groups (P&lt;0.001). The EPA group maintained body weight for an extended duration (20 days) compared to the oxypurinol (5 days) and combination (8 days) groups (P&lt;0.05). EPA (18.2&plusmn;3.2 pg/ml) and combination (18.4&plusmn;3.7 pg/ml) groups had significantly higher 8-OH-dG levels than the control group (12.9&plusmn;1.4 pg/ml, P&le;0.05) indicating increased oxidative damage to DNA. mRNA levels of GPx1, MURF1 and MAFbx were higher following EPA treatment compared to control (P&le;0.05). Whereas oxypurinol was associated with higher GPx1, MnSOD, CAT, XDH, MURF1, MAFbx and UbB mRNA compared to control (P&le;0.05). Activity of total SOD was higher in the oxypurinol group (32.2&plusmn;1.5 U/ml) compared to control (27.0&plusmn;1.3 U/ml, P&lt;0.01), GPx activity was lower in the EPA group (8.76&plusmn;2.0 U/ml) compared to control (14.0&plusmn;1.9 U/ml, P&lt;0.05), and catalase activity was lower in the combination group (14.4&plusmn;2.8 U/ml) compared to control (20.9&plusmn;2.0 U/ml, P&lt;0.01). There was no change in XO activity. The increased rate of weight decline in mice treated with oxypurinol indicates that XO may play a protective role during the progression of cancer cachexia, and its inhibition is detrimental to outcomes. In combination with EPA, there was little significant improvement from control, indicating oxypurinol is unlikely to be a viable treatment compound in cancer cachexia.<br /

Measurements of the Cosmological Evolution of Magnetic Fields with the Square Kilometre Array

We investigate the potential of the Square Kilometre Array (SKA) for measuring the magnetic fields in clusters of galaxies via Faraday rotation of background polarised sources. [...] We find that about 10 per cent of the sky is covered by a significant extragalactic Faraday screen. Most of it has rotation measures between 10 and 100 rad/m/m. We argue that the cluster centres should have up to about 5000 rad/m/m. We show that the proposed mid frequency aperture array of the SKA as well as the lowest band of the SKA dish array are well suited to make measurements for most of these rotation measure values, typically requiring a signal-to-noise of ten. We calculate the spacing of sources forming a grid for the purpose of measuring foreground rotation measures: it reaches a spacing of 36 arcsec for a 100 hour SKA observation per field. We also calculate the statistics for background RM measurements in clusters of galaxies. We find that a first phase of the SKA would allow us to take stacking experiments out to high redshifts (>1), and provide improved magnetic field structure measurements for individual nearby clusters. The full SKA aperture array would be able to make very detailed magnetic field structure measurements of clusters with more than 100 background sources per cluster up to a redshift of 0.5 and more than 1000 background sources per cluster for nearby clusters, and could for reasonable assumptions about future measurements of electron densities in high redshift clusters constrain the power law index for the magnetic field evolution to better than dm=0.4, if the magnetic field in clusters should follow B ~ (1+z)^m.Comment: 12 pages, 10 figures, 3 tables, accepted by MNRAS, minor correction to eq (5